                         SEQUENCE LISTING

<110>  IPSEN PHARMA S.A.S.
       DONG, Zheng  Xin
 
<120>  Analogues of Glucose-Dependent Insulinotropic Polypeptide

<130>  177P2/PCT2

<150>  61/188,191
<151>  2008-08-07

<150>  61/200,629
<151>  2008-12-02

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  2

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  3
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid

<400>  3

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  4
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  4

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  5
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  5

Tyr Xaa Glu Gly Thr Phe Ile Ser Xaa Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  6

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  7
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  7

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  8

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  9

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  10

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  11
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  11

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  12
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  12

Tyr Xaa Glu Gly Thr Phe Ile Xaa Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  13
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  13

Tyr Xaa Glu Xaa Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  14

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  15

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  16

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  17
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  17

Tyr Xaa Glu Xaa Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  18

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  19

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  20

Tyr Xaa Glu Gly Thr Phe Ile Xaa Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  21

Tyr Xaa Glu Gly Thr Phe Ile Ser Xaa Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  22

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  23

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  24
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  24

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  25
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  25

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  26
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  26

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  27
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  27

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  28
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  28

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  29
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  29

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Xaa Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  30
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  30

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Xaa Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  31
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  31

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  32
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  32

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  33
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  33

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Xaa Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  34

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  35

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  36

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  37

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  38

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  39
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  39

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  40
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  40

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Xaa His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  41

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  42
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  42

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  43
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  43

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  44
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  44

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  45
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  45

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  46
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  46

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  47
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  47

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  48
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  48

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  49
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  49

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  50
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  50

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  51
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  51

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  52

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  53
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  53

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  54
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  54

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  55
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  55

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  56
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  56

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  57
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  57

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  58
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  58

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  59
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  59

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  60
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  60

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  61
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  61

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  62
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  62

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  63
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  63

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  64
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  64

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  65
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  65

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  66
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  66

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  67
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 3,4-dehydroproline (Dhp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  67

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  68
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  68

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  69
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  69

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  70
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  70

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  71
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  71

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  72
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  72

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  73
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 3-hydroxyproline (3Hyp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  73

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  74
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  74

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  75
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  75

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  76
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  modified with N-propylsuccinimide (Psu)

<400>  76

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Cys Gln 
        35                  40          


<210>  77
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  77

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  78
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  78

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  79
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  79

Tyr Ala Pro Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  80
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  80

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  81
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  modified with N-propylsuccinimide (Psu)

<400>  81

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Cys Thr Gln 
        35                  40          


<210>  82
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  modified with N-propylsuccinimide (Psu)

<400>  82

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Cys Ile Thr Gln 
        35                  40          


<210>  83
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  modified with N-propylsuccinimide (Psu)

<400>  83

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys Cys Asn Ile Thr Gln 
        35                  40          


<210>  84
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  modified with N-propylsuccinimide (Psu)

<400>  84

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Cys Lys His Asn Ile Thr Gln 
        35                  40          


<210>  85
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  85

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  86
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  86

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  87
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  87

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  88
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  modified with N-propylsuccinimide (Psu)

<400>  88

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Cys Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  89
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  modified with N-propylsuccinimide (Psu)

<400>  89

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Cys Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  90
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  90

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  91
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  91

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  92
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  92

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  93
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  modified with N-propylsuccinimide (Psu)

<400>  93

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Cys Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  94
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  94

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  95
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  95

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  96
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  96

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gln 
        35                  40              


<210>  97
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with N-propylsuccinimide (Psu)

<400>  97

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  98
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with N-propylsuccinimide (Psu)

<400>  98

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  99
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  99

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  100
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  100

Tyr Ala Pro Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  101
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  101

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  102
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with N-propylsuccinimide (Psu)

<400>  102

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  103
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  modified with N-propylsuccinimide (Psu)

<400>  103

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Cys His Asn Ile Thr Gln 
        35                  40          


<210>  104
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  104

Xaa Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  105
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  105

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  106
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  106

Xaa Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  107
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  107

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  108
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  108

Tyr Xaa Pro Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  109
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  109

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  110
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  110

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  111
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  111

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  112
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = N-methyl-tyrosine (NMe-Tyr)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  112

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  113
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  113

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  114
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  114

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  115
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  115

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  116
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  116

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  117
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  117

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  118
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  118

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  119
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  119

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  120
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)

<400>  120

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  121
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  121

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  122
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)

<400>  122

Tyr Ser Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  123
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa =  alpha-aminobutyric acid (Abu)

<400>  123

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


